![]() However, these relationships vary between ethnic groups. ![]() Objectives Apolipoprotein E gene ( APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. © The Author(s) 2015.Īssociation of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-CaribbeansĪrmand, Christophe Bangou, Jacqueline Blanchet-Deverly, Anne Numeric, Patrick Fonteau, Christiane Michel, Carl-Thony Ferdinand, Séverine Bourrhis, Véronique Vélayoudom-Céphise, Fritz-Line Our results show that carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis. The TT genotype of rs688 in the LDLR gene was not found to be associated with elevated levels of total cholesterol or LDL-C. We found significant association between LDL-C (odds ratio = 3.3, 95% confidence interval : 1.9-5.7) and marginal association with TG (OR = 1.7, 95% CI: 1.0-2.9) of atherogenic risk in women carriers of the ApoE4 isoform compared to ApoE3. Anthropometric features and biochemical profile were evaluated, and genotyping of single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene and rs688 in the LDLR gene was determined by TaqMan assays. We studied 400 women from Southwest Mexico. It was demonstrated that carriage of the delta32 polymorphism for the CCR5 gene, V64/ polymorphism for the CCR2 gene, e2/e3/e4 for the apoE gene, 元3P for the ITGB3 gene, as well as H63D and S65C polymorphisms for the HFE gene does not influence on predisposition to the longevity carriage of the 282 Y allele for the HFE gene negatively influences on the longevity carriage of the heterozygous genotype for the R72P polymorphism for the p53 gene correlates with the longevity of elderly people.Įlevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene.Ĭahua-Pablo, Gabriel Cruz, Miguel Moral-Hernández, Oscar Del Leyva-Vázquez, Marco A Antúnez-Ortiz, Diana L Cahua-Pablo, José A Alarcón-Romero, Luz Del Carmen Ortuño-Pineda, Carlos Moreno-GodÃnez, Ma Elena Hernández-Sotelo, Daniel Flores-Alfaro, EugeniaĪpolipoprotein E ( ApoE) 4 isoform has been associated with elevated levels of cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs), meanwhile several polymorphisms in the LDL receptor (LDLR) gene have been associated with increased levels of total cholesterol and LDL-C. In order to estimate the distribution of some polymorphisms for the CCR5, CCR2, apoE, p53, ITGB3, and HFE genes in Russian long-livers from Western Siberia, a sample of 271 individuals (range 90-105 years) was examined. ![]() Ivanoshchuk, D E MikhaÄlova, S V Kulikov, I V Maksimov, V N Voevoda, M I Romashchenko, A G
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